Kirchin MA, Runge VM (2003): Contrast agents for magnetic resonance imaging: safety update. ISIS Medical Media, OxfordĮarls JP, Bluemke DA (1999) New MR imaging contrast agents. Eur Radiol 15:1607–1614ĭawson P, Cosgrove DO, Grainger RG (eds) (1999) Textbook of Contrast Media. Our next steps are to manufacture Mn-P圜3A on a larger scale and conduct additional preclinical safety studies before we can begin testing in human patients.Bellin M-F, Webb JAW, Der Molen AJ, Thomsen HS, Morcos SK (2005): Safety of MR liver specific contrast media. Gale explains, "While we did not test it here, we believe that having an alternative route of elimination through the liver will provide an efficient mechanism for elimination of Mn-P圜3A in patients with kidney disease and prevent any retention of the contrast agent in the body. As in the mouse study, Mn-P圜3A was quickly excreted though both kidney and liver clearance, and there was no evidence of the release of free manganese. The scans were performed under identical conditions - the scanner used, the dosages and imaging protocols were the same as would be used for human patients - and the enhanced images of major arteries, kidneys, livers and specific muscles produced by both agents were comparable. For the current study, the researchers compared the use of Mn-P圜3A to a commonly used GBCA in a baboon model.Įach animal underwent two MR imaging sessions, one with Mn-P圜3A and one with the GBCA. Previous studies conducted by the team in mouse models showed that Mn-P圜3A was very resistant to the release of manganese ions that it provided good enhancement of blood vessels, liver and kidneys that more than 99 percent was excreted from the body within 24 hours, and that it was eliminated by both the liver and the kidneys, reducing the likelihood of prolonged retention in subjects with poor kidney function. The body has natural mechanisms to process and excrete excess manganese, but any gadolinium that is released from GBCAs is likely to be retained in the body indefinitely. FDA to reiterate the need for caution and restraint in the use of the agents and the European Medical Association to remove three of seven previously approved agents from the market and restrict the use of others earlier this year.Ĭaravan and his colleague Eric Gale, PhD, of the Martinos Center developed their manganese-based agent Mn-P圜3A based on two properties of the element: its ability to produce an MR signal comparable to that of GBCAs and the fact that that - in contrast to gadolinium, which is not naturally found in the human body - manganese is an essential element, and intake of small amounts is required for vital bodily functions. More recent reports finding gadolinium deposits in the brains and other organs of patients have added to concerns about the safety of GBCAs, leading the U.S. every year because of the inability to use GBCAs in patients with poor renal function." We estimate that around 2 million contrast-enhanced scans are not performed in the U.S. "All current FDA-approved MR contrast agents contain gadolinium, which in 2006 was associated with a devastating condition called nephrogenic systemic fibrosis in patients with impaired kidney function. "About 40 percent of MRI procedures use a contrast agent to produce a signal that can detect cancers, diagnose aneurysms or arterial narrowing, or identify the area of a heart damaged by a heart attack," says Peter Caravan, PhD, of the Martinos Center for Biomedical Imaging and co-director of the Institute for Innovation in Imaging at MGH, corresponding author of the Radiology paper.
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Pic 5: The bag easily fits everything in the main section. Running shoes (with a pair of socks stuffed in each shoe) Everything I will pack, ready to go into the bag. To give you an idea what this bag holds, here’s what went into it on my recent five week volunteer trip to Chiang Mai, Thailand. Keeping heavier items toward the back/bottom eliminates the issue and the bag stands up beautifully on its own. (Ideally I would prefer it to have four spinner wheels rather than two roller wheels.) However, I’ve finally found a solution to this by using packing cubes and putting a little more thought into how I arrange what’s inside the bag. I’ve never had anything damaged because of it tipping, but it’s a little bit of a nuisance to have to find a place to prop it up or deal with picking it back up every time it tips. My least favorite thing about this bag is its tendency to tip over when standing upright. (It also has a handle at the top and two straps that Velcro together across the body to assist with lifting/carrying.) The bag is very easy to pull, even fully stuffed. Most airlines limit each bag to 50lbs (23kgs), so filling the bag to capacity, I’ve gotten to that limit, but never over. It provides the perfect quantity to weight ratio. My favorite thing about this bag is that, it’s almost impossible to pack it overweight. It’s a great size for storing under a bed and rolling out as needed. I’ve found myself using the bag during my trip like a drawer or chest, in lieu of an actual dresser. The U-shaped opening makes it easy to see everything in the bag and get to the item I want without digging around for it. With the packing cubes, it’s easy to stay organized throughout my trip and keep all my belongings in the same place. As a bonus, it does double duty once at my destination. It’s been durable and easy to maneuver through airports, city streets, and African soil. The bag has been perfect for my move to Hawaii and most recently for a five week stay in Thailand. (There’s also a medium size option, which would be a shorter trip or a more minimalist packer.) The bag comes in a variety of colors, and while it may not be the most polished look, it definitely stands out on a luggage carousel! I initially bought the bag to take to Kenya for a two-year term in the Peace Corps, so I purchased two of the extra large size. It weighs just under 8 lbs (3.5kg) which is really light for its size. It hasn’t disappointed! The wheels are great, as is the wide opening and soft construction. Having traveled with every bag style from military duffle to hiking backpack to traditional, old-fashioned suitcase, I picked this hybrid style, hoping it would be the best of all worlds. I also knew if the bag didn’t hold up in any way (unlikely, given the rigorous testing of all L.L.Bean bags) I could have it repaired or return it without any hassle. When choosing luggage, I went with this company because of that guarantee, knowing that if I took the bag on a trip (or ten) and didn’t like the way it performed, I could return it, no questions asked. I have a lot of experience with L.L.Bean products, and my favorite thing about the company is their lifetime guarantee. (On my own time, I pack a lot lighter and usually in a backpack.) As a volunteer, I tend to bring those “just in case” kind of items, as well as supplies necessary to the trip.įor these trips, I’ve found the perfect bag: the L.L.Bean Quickload Upright Rolling Duffle ($179 US). Since I most often travel with nonprofit organizations and am usually interacting with children or needing to keep within a dress code, I don’t pack like a tourist. I currently live on the island of Oahu in tropical Hawaii, where I work in the hospitality industry. I’ve traveled to destinations on five continents and am itching to put my feet on the last two ( South America and Antarctica). At the tender age of 13 the travel bug bit me and I haven’t ever recovered. I particularly recommend the Light Grey Heather color for those interested in adding a subtle twist to their travel designs.The following L.L.Bean rolling duffle review has been submitted by Leah Buckman. It is ideal for overnight trips, hiking expeditions, and short domestic flights. Given its size, the Rolling Adventure Duffle may be better suited for non-flight purposes-but there are certainly many opportunities which would call for this item. I'm off to the Middle East in a few weeks, and I'll certainly be using this on my escapades. I recommend this bag for people who travel on the road, hikers and campers, and the occasional airline flyer. This bag is large enough to keep all which you desire to bring along while not being cumbersome. Here are my overall ratings for this product (on a five-star scale):įor those looking for adventure, the LL Bean Rolling Adventure Duffle may just be the right luggage bag to bring with you. Because Webster’s unabridged 1934 offers gee whilikins as a variant of gee whiz. You think we’re starting to digress, but we’re not. Suddenly, gee seems like an expression in place of “Jesus” rather than “God,” which of course would seem obvious, phonetically speaking. Gee whiz - a near caricature of 1950s juvenile expressions - first appeared in an 1883 edition of “The Warren Ledger,” a Pennsylvania newspaper, which may have taken from Cody and Arlington’s “Life on the Border” (1876): “Gee-wees!…I’ll bet one hundred dollars on that hand!” Others date it to 1871, but it hardly matters at this point because it’s all probably an evolution of jeez from the 1830s. Gee, on its own, is a bit harder to pin down. Gosh came a little bit later, around 1757, probably a derivation of “by gosse” from Nicholas Udall’s comic play “Ralph Roister Doister.” You’re already familiar with some related wordplay: Golly dates back to 1743 England, according to some sources. Some sources suggest children in 18 th and 19 th century England were encouraged to use “g” words in place of God, but the tradition of avoiding sacred words with substitutions goes back further, to old Hebraic and Middle English forms. Gee might, then, stand in place of “God,” lest speakers use the lord’s name in vain. In any case, gee willikers is a minced oath, a euphemistic expression used in place of something more hideously offensive. (And I know what you’re thinking, but no, surprisingly none of this is related to the gee-haw whammy diddle.) Still, gee whillikers is also permitted and arguably closest to the origin, though golly gee willikers may have something to say about that. But gee willickers is also occasionally acceptable. Gee willikers seems to be the most proper. The proper spelling is… well, there isn’t a proper spelling. And just as any spell checking goes, you start with a Google search and end with excerpts from Archibald Henderson’s 1911 biography on Mark Twain, curiously titled “Mark Twain.”īut first things first, Mark Twain later. We agreed to spell check the word and get back to each other. More to the point, it turns out that I didn’t know how to spell geewillickers either, so the score was never actually evened. So consider us even.” That’s not really an equitable tit for tat, but Claire is nothing if not generous. Sorry.”Ĭlaire took the offense in stride: “I didn’t know that’s how you spelled geewillickers. I didn’t even bother to check schedules when I sent that around. OK, they’re usually not work-related.ĭuring a recent a chat around the DMS blog office, someone (me) acknowledged his (my) scheduling mistake in Outlook Calendar by saying, “Oh Em Geewillickers, Claire (our blog editor). Watercoolering highlights the things - not always work-related - that we’re talking about around the office. “OMG! The Mississippi is my favorite,” said Mark Twain. Offers easy conversion of Mac/Windows MBOX to PST. Its main features are: Download trial 100 Secure. Launch & run mentioned Converter on your Mac machine. It has a limitation of exporting only 25 emails from each folder. MacSonik Outlook PST Converter is a standalone utility to convert PST files into various file formats and email clients on a Mac machine. Use the trial version and it will help you to try all the software features before purchasing the tool. It supports different email clients such as Apple Mail, Thunderbird, Google Takeout, Eudora, Zoho Mail, etc. Just Download the mentioned Mac Mail to PST Converter for free of cost. Mbox to Outlook Transfer is the only tool that works with all types of MBOX mailboxes generated by Windows, Linux and Mac email clients. 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He’s a nasty amalgam: entitled entertainment consumer, hideous fanboy, male privilege run amok, black hat deconstruction of Manifest Destiny. He’s the Easter egg-hunting theorist who thinks Westworld holds a secret just for him - a maze, a hidden level, high stakes story that offers the ultimate catharsis. One nameless dude (Ed Harris) has been coming to Westworld for 30 years - for so long, “it feels like I was born here.” He dresses all in black, he wields customized weaponry, and he seems to have conformed completely to a villainous image of his own creation. It also asks us to rethink other, weightier things, like our national mythology and how the west was really won. What happens in Westworld, stays in Westworld.Īnd so Westworld asks us to recognize ourselves in its story. Many of them, mostly men, choose wanton nihilism. With no social or mortal consequence at all, save the cost to their conscience. They can do anything they want to their warm and fleshy and oh, so comely hosts. It keeps the turnstiles churning by catering to guests looking for rank escapism, who prefer to romp and rage and Bada Bing! with no code at all. Regardless, modern day Westworld is a Deadwood of moral ambiguity. In its best possible form, this miraculous sandbox is Fantasy Island stuck in oater mode. There are intimations in Westworld that once upon a time, the showrunners were interested in provoking similar uplift and improvement. We remember that the heyday of the western was Production Code-era Hollywood, when every movie was vetted for immoral content, making them intrinsically moralistic. But Westworld stands for all kinds of Dream Factory products and periods, past and present. In this way, Westworld effectively captures the experience of open world action-adventure games like Grand Theft Auto, Assassin’s Creed, and Minecraft. We see in her story a familiar tale of innocence lost, a comment on the clichés of grittiness and realism, and a high concept metaphor for the life of a working actress, among other things. But the queasy concept encourages a critical posture toward what Westworld puts on screen. Like all hosts, Dolores is memory-wiped each night and made to repeat this awful storyline the next day, as if for the first time. That should leave a mark - except it doesn’t. Every day, she wakes up with a smile, greets her beloved father, rides into the town of Sweetwater for supplies, and gallops home to find rapacious bandits murdering her parents. The oldest android in service is one of the youngest in appearance, and she currently performs the part of an optimistic rancherette named Dolores (Evan Rachel Wood). Each synthetic thespian or “host” is scripted with a unique story that contributes to a sprawling, splintering soap opera, all controlled by remote, unseen showrunners. It’s The Big Valley, cast with a bonanza of uncanny valley actors. This is the best kind of sci-fi: It entertains you and makes you think.“Westworld” is a themed resort, an ersatz Frontierland produced with meticulous verisimilitude, populated with near-human Tomorrowland automatons. Are the makers of Westworld actually asking us to sympathize with robots rising up against humans? They sure are - and they're doing a bang-up job of it, too. Ed Harris' Man in Black is the most obvious one, a guest taking vile jollies in his freedom to mess with Hosts like Evan Rachel Wood's doe-eyed Southern belle Dolores and James Marsden's square-jawed gunslinger Teddy.Īs we watch the sympathetic Hosts take physical and emotional abuse from both Newcomers and the scientists who created them, it becomes clear that no one's a hero here - not the thoughtless humans, not the helpless robots, and most definitely not the cynical people who write the park's scripts and steer the Host/Newcomer interactions. 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The Roblox Creator Challenges took place inside of three experiences, Galactic Speedway Creator Challenge, Jurassic World Creator Challenge, Godzilla Creator Challenges, and PC Creator Challenge. Learn all about the newest promo codes, accessories, events, and more This guide features a complete and up-to-date list of all the currently active Roblox Promo Codes, events, and free items If you're looking to deck out your avatar with some awesome free accessories, then you've come. Creator Challenges were implemented by Roblox as a way for players to learn the ins and outs of Roblox studio, Roblox's game development program, while also playing minigames, exploring inventive areas, and having fun with friends. By: Pro Game Guides Staff - Updated: May 11, 2023. DoYourData Super Eraser For Macĭo You Data is one of the best permanent erasers for Mac as it securely removes the data from your hard drive. The app is available for free on Mac Store. 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Then point the front camera of your device towards the QR code and the box will light up.īlackbox Level 45/ Enclosed Orange Box Solution:Ĥ5: This is also a secret level. To unlock the level, open ‘Safari’ and go to Blackbox’s website through the App Store description. As you open the website tilt your device upside down a couple of times. The red fluid will move to the other side and reveal the lock symbol which indicates locking the orientation of your device. Pull up the ‘ Lock Orientation ’ button and toggle it on. Go back to the website and turn the device upside down once again. You’ll spot a text that says “BLACKBOX://META” on the bottom. Copy the shown text and paste it on the address bar of ‘Safari’, and after pressing enter choose ‘Open on Blackbox ’ on the new appeared pop-up. Go back to ‘Safari’ and enter ‘BLACKBOX://’ followed by the emoji Lock (?). Choose again yes to open the link on Blackbox and the secret level will be unveiled although locked. Open again ‘Safari’ and add ‘BLACKBOX://’ to the address bar followed by a key emoji (?). Open again through the app and the level will be unlocked, although it will be all dark with no clue at all. In order to light up the secret orange box go to ‘Safari’ and in the address bar add “BLACKBOX://” followed by the emoji Lightbulb (?). Open the link in Blackbox and the box will light up.īlackbox Level 46/ Enclosed Pink Box Solution:Ĥ6: After pressing the share button on the bottom left you’ll unlock level 45 and 46 likewise. Blackbox Level 41/ Enclosed Light Orange Box Solution:Ĥ1: Launch the app at the bottom left of your device’s main screen.To complete this level you need QR codes of 3 different colors (Blue, Green & Pink). It may be ‘Settings’, ‘Safari’, ‘Messages’ or whatsoever. 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In order to light up the secret orange box go to ‘Safari’ and in the address bar add “BLACKBOX://” followed by the emoji Lightbulb (□). To complete this level you need QR codes of 3 different colors (Blue, Green & Pink). Williams won a Grammy in 2003 for producing Timberlake’s first solo album, Justified. The band reunited in 2017 with the album No_One Ever Really Dies, which took a more political stance than their previous work. Williams, Hugo and drummer Shay Haley formed the band N.E.R.D, which released its first album, In Search Of…, in 2001, followed by Fly or Die (2004), Seeing Sounds (2008) and Nothing (2010). They were inducted into the Songwriters Hall of Fame in 2022. Blige, “Drop It Like It’s Hot” by Snoop Dogg and “Rock Your Body” by Justin Timberlake. The Neptunes produced songs such as “Steal Away” by Mary J. In 1994, they produced the song “Tonight’s the Night” on Blackstreet’s debut album. Music producer Teddy Riley signed them, and the Neptunes eventually became a production team. He told Vanity Fair that his early influences were “hip-hop, hair band music and grunge.”Ī percussionist for his high school band, he met saxophonist Chad Hugo at band camp, and the two became friends through music, forming a band called the Neptunes. Pharrell Williams was born on April 5, 1973, to parents Pharoah Williams and Caroline Randall Williams in Virginia Beach, Virginia. “That song would never have been the same song if it had been for my album,” he said, “but because it was for an animation, the only thing I could do was to put pure emotion into it-make a song for a man just walking down the street with pure happiness because he fell in love for the first time.” In 2014, Time magazine named him one of the 100 Most Influential People in the World. His song “Happy,” written for Despicable Me 2, was a top Billboard Hot 100 chart hit for 10 straight weeks and was nominated for an Academy Award for best original song. He’s written scores and songs for movies, including the animated Despicable Me and its sequels. Diddy, Snoop Dogg, No Doubt, Usher and Limp Bizkit. Williams also produced songs for some of the biggest music stars, including Nelly, Jay-Z, Britney Spears, Busta Rhymes, P. He has been part of the famous production duo The Neptunes and co-founded and sang lead vocals for the alt-rock/hip-hop band N.E.R.D. Pharrell Williams went from teenage prodigy to a 13-time Grammy winner while carving out a path as one of the most original and versatile figures in the music industry. |